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細胞科学部-業績一覧

業績

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　　　　　　　　　　　　　　　　　　　　下線は細胞科学部員　†：equal contribution　*：Corresponding author

2026年

  • Khalil J, Miyauchi K, Suzuki Y, Ki S, Harada Y, Sasaki T, Yamamoto Y, Hashimoto R, Yamamoto T, Matsuda M, Koseki H, Nakayama M, Fukasawa M, Wakita T, Ueno H, Noguchi K, Takayama K, Kubo M. The role of IL-4+ memory T cells in SARS-CoV-2 booster vaccination. Int Immunol. 38, 41-55, 2026.
  • Hagiwara K*, Shibata H, Tobiume M, Sato Y, Ohto K, Okabayashi S, Nakano N, Horiuchi M, and Ono F. Strain traits of intracranially administered L-type bovine spongiform encephalopathy prions are not significantly modified during intraspecies transmission in cynomolgus monkeys. Microbiol Immunol., 70, 166-174, 2026.


2025年

  • Goto K, Tateishi M and Shirakawa R*, Use of Biotin-Labeled Geranyl Pyrophosphate for Analysis of Ykt6 Geranylgeranylation. Methods Mol. Biol., 2887, 93-102, 2025.
  • Tateishi M, Goto K, Hishinuma E, Matsukawa N, Kishimoto T, Tanaka K, Horiuchi H, Fukasawa M and Shirakawa R*, Double prenylation of budding yeast Ykt6 regulates cell wall integrity and autophagy. J. Biol. Chem., 301, 108384, 2025.
  • Shibata H, Ono F, Sato Y, Ohto K, Nakano N, Imamura M, Horiuchi M, Tobiume M, and Hagiwara K*. Lack of Evidence for transmission of atypical H-Type bovine spongiform encephalopathy prions (H-BSE Prions) by intracranial and oral challenges to nonhuman primates. Immunol., 69, 25-34, 2025.
  • Fukuda Y, Ishikawa A, Ishiyama R, Takai-Todaka R, Haga K, Someya Y, Kimura-Someya T, Katayama K. Establishment of a Novel Caco-2-Based Cell Culture System for Human Sapovirus Propagation. Genes Cells, 30, e70007, 2025.
  • Kobari Y, Miyata N, Takayama J, Saijo N, Suzuki T, Kure S, Kikuchi A, Tamiya G, Takizawa T, A Japanese Case of Lenz-Majewski Syndrome With a Novel PTDSS1 Variant. Mol Genet Genomic Med., 13(6), e70112, 2025.
  • Suzuki R, Yato K, Tosaka T, Matsuda M, Hmwe SS, Fukasawa M, Fukuhara T, Matsuura Y, Muramatsu M, Wakita T. The Hepatitis C Virus Genotype 3a S310 Strain Permits Claudin-1-Independent Entry. Microbiol Immunol. 69, 544-552, 2025.
  • Yamamoto Y, Inoue T, Sugiyama N, Furukawa M, Sato K, Onodera T, Takahashi Y, Wakita T, Fukasawa M, Noguchi K. Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2. Sci Rep. 15, 26469, 2025.
  • Shinkai-Ouchi F, Shindo M, Ogawa M, Doi N, Fukasawa M, Yasuko Ono. Data for comparative proteomic analysis of Calu-3 cells infected with SARS-CoV-2 in the absence and presence of calpeptin. J. Proteome Data & Methods, 7, 3, 2025.
  • Imamura M*, Hagiwara K, Tobiume M, Ohno M, Iguchi H, Takatsuki H, Mori T, Atarashi R, Shibata H and Ono F. Administration of L-Type bovine spongiform encephalopathy to macaques to evaluate zoonotic potential. Emerg Infect Dis., 31, 986-990, 2025.
  • Oka T*, Okemoto-Nakamura Y, Takagi H. CD36 is required for human sapovirus propagation. J. Virol., 25; 99(11): e0132525, 2025.

 

2024年

  • Oka T., Li T.-C., Yonemitsu K., Ami Y., Suzaki Y., Kataoka M., Doan Y.H., Okemoto-Nakamura Y., Kobayashi T., Saito H., Mita T., Tokuoka E., Shibata S., Yoshida T., and Takagi H., Propagating and banking genetically diverse human sapovirus strains using a human duodenal cell line: investigating antigenic differences between strains. J. Virol., 98, e0063924, 2024.
  • Kimura-Someya T*, Katsura K, Kato-Murayama M, Hosaka T, Uchikubo-Kamo T, Ihara K, Hanada K, Sato S, Murayama K, Kataoka M, Shirouzu M, Someya Y. Structural analyses of the GI.4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies. J. Virol., 98, e0019724, 2024.
  • Shimasaki K., Okemoto-Nakamura Y., Saito K., Fukasawa M., Katoh K*. and Hanada K*., A high-resolution phase-contrast microscopy system for label-free imaging in living cells. Cell Struct. Funct., 49, 21-29, 2024.
  • Shimasaki K*, Okemoto-Nakamura Y, Saito K, Fukasawa M, Katoh K, Hanada K*, Deep learning-based segmentation of subcellular organelles in high-resolution phase-contrast images. Cell Struct. Funct., 49, 57-65, 2024.
  • Murae M†, Sakai S†, Miyata N, Shimizu Y, Okemoto-Nakamura Y, Kishimoto T, Ogawa M, Tani H, Tanaka K, Noguchi K, Fukasawa M. Inhibition mechanism of SARS-CoV-2 infection by a cholesterol derivative, Nat-20(S)-yne. Biol. Pharm. Bull., 47, 930-940, 2024.
  • Inoue T, Yamamoto Y, Sato K, Okemoto-Nakamura Y, Shimizu Y, Ogawa M, Onodera T, Takahashi Y, Wakita T, Kaneko M, Fukasawa M*, Kato Y*, Noguchi K*. Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies. iScience, 27, 109363, 2024.
  • Watanabe M, Maekawa M, Miyoshi K, Sato T, Sato Y, Kumondai M, Fukasawa M, Mano N. Global and Targeted Metabolomics for Revealing Metabolomic Alteration in Niemann-Pick Disease Type C Model Cells. Metabolites, 14, 515, 2024.
  • Ito M, Jie L, Fukasawa M, Tsutsumi K, Setou M, Kohara M, Suzuki T. Induction of phospholipase A2 group 4C by hepatitis C virus infection regulates lipid droplet formation. JHEP Rep., 7, 101225, 2024.

 

2023年

  • Yamaji T*, Homma Y. Construction of Sphingolipid Remodeled Cells by Genome Editing. Methods Mol Biol, 2613, 111-125, 2023.
  • Mizuike A, Sakai S, Katoh K, Yamaji T, Hanada K*. The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi. J Cell Biol, 222, e202111069, 2023.
  • Nakayama H, Hanafusa K, Yamaji T, Oshima E, Hotta, Iwabuchi K. Phylactic role of anti-lipoarabinomannan IgM directed against mannan core during mycobacterial infection in macrophages. Tuberculosis, 143, 102391, 2023.
  • Gehin C, Lone MA, Yamaji T et al (77th/85). CERT1 mutations perturb human development by disrupting sphingolipid homeostasis. J Clin Invest, 133, e165019, 2023.
  • Abe T, Marutani Y, Deng L, Matsui C, Fukasawa M, Suzuki R, Wakita T, Matsuura Y, and Shoji I. Hepatitis C virus disrupts Annexin 5-mediated occludin integrity through downregulation of PKCa and PKC𝜂 expression, thereby promoting viral propagation. J Virol, 97, e0065523, 2023.
  • Ishii Y, Yamaji T, Sekizuka T, Homma Y, Mori S, Takeuchi T, Kukimoto I. Folliculin Prevents Lysosomal Degradation of Human Papillomavirus to Support Infectious Cell Entry. J Virol, 97, e0005623, 2023.
  • Someya K., Okemoto-Nakamura Y., Kurata T., Kanbayashi D., Saito N., Itamochi M., Otsuki N., Hanada K. and Takeda M. Establishment of measles virus receptor-expressing Vero cells lacking functional poliovirus receptors. Microbiol Immunol., 67(3), 166-170, 2023
  • Ogawa M, Murae M, Mizukami T, Gemba R, Irie T, Shimojima M, Ebihara H, Noguchi K, Fukasawa M*, The combination of levodopa with levodopa-metabolizing enzyme inhibitors prevents severe fever with thrombocytopenia syndrome virus infection in vitro more effectively than single levodopa. Journal of Infection and Chemotherapy. 29, 549-553, 2023.
  • Miyosh K, Hishinuma E, Matsukawa N, Shirasago Y, Watanabe M, Sato T, Sato Y, Kumondai M, Kikuchi M, Koshiba S, Fukasawa M, Maekawa M, Mano N. Global proteomics for identifying the alteration pathway using model cells of Niemann–Pick disease type C. Int J Mol Sci, 24, 15642, 2023.
  • Yamamoto Y, Nakano Y, Murae M, Shimizu Y, Sakai S, Ogawa M, Mizukami T, Inoue T, Onodera T, Takahashi Y, Wakita T, Fukasawa M, Miyazaki S, Noguchi K. Direct inhibition of SARS-CoV-2 spike protein by peracetic acid. Int J Mol Sci., 24, 20, 2023.
  • Ohta K, Saka N, Fukasawa M, Nishio M. Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-1. Front Microbiol, 14, 1192956, 2023.
  • Ogawa M, Murae M, Fukushi S, Noguchi K, Ebihara H, Fukasawa M*. An in vitro short-term treatment with black tea-derived theaflavins reduced infectivity of SARS-CoV-2 in saliva. BPB_Rep, 6, 163-165, 2023.
  • Goto A* and Hanada K. Protocol for casein kinase 1γ3 CSNK1G3 gene knockout and recombinant gene expression in cultured HeLa cells. STAR Protocols, 4: 102251, 2023.

 

2022年

  • Konan KV, Ogbamikael SA, Yager E, Yamaji T, Cerone J, Monaco-Brown M, Barroso M, Hanada K. Modulation of Zika virus replication via glycosphingolipids. Virology, 572, 17–27 2022.
  • Saito K*, Shimasaki K, Fukasawa M, Suzuki R, Okemoto-Nakamura Y, Katoh K, Takasaki T, Hanada K. Establishment of Vero cell lines persistently harboring a yellow fever virus 17D subgenomic replicon. Virus Res. 322,198935, 2022.
  • Goto A, Sakai S, Mizuike A, Yamaji T, Hanada K*. Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide. iScience, 25, 164624 2022.
  • Yamamoto Y, Inoue T, Murae M, Fukasawa M, Kaneko MK, Kato Y, Noguchi K. SARS-CoV-2 spike protein mutation at cysteine-488 impairs its Golgi localization and intracellular S1/S2 processing. Int J Mol Sci., 23, 15834, 2022.
  • Kumagai K*, Sakai S, Ueno M, Kataoka M, Kobayashi S, Hanada K*. Chlamydial Infection-Dependent Synthesis of Sphingomyelin as a Novel Anti-Chlamydial Target of Ceramide Mimetic Compounds. J. Mol. Sci, 23, 14697, 2022
  • Li X, Ito M, Aoyagi H, Murayama A, Aizaki H, Fukasawa M, Kato T, Wakita T, Suzuki T. Development and use of a kinetical and real-time monitoring system to analyze the replication of hepatitis C virus. Int J Mol Sci., 23, 8711, 2022.
  • Goto A†, Egawa D†, Tomishige N*, Yamaji T, Shimasaki K, Kumagai K, Hanada K*. Involvement of a cluster of basic amino acids in phosphorylation-dependent functional repression of the ceramide transport protein CERT. Int. J. Mol. Sci, 23, 8576, 2022.
  • Shimasaki K, Kumagai K*, Sakai S, Yamaji T, Hanada K*. Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering Throughout the Endoplasmic Reticulum. Int. J. Mol. Sci, 23, 4025 2022.
  • Liu Y, Katoh H, Sekizuka T, Bae C, Wakata A, Kato F, Sakata M, Yamaji T, Wang Z, Takeda M. SNARE protein USE1 is involved in the glycosylation and the expression of mumps virus fusion protein and important for viral propagation. PLoS Pathog, 18, e10101949 2022.
  • Mori Y, Sakata M, Sakai S, Okamoto T, Nakatsu Y, Taguwa S, Otsuki N, Maeda Y, Hanada K, Matsuura Y, Takeda M. Membrane sphingomyelin in host cells is essential for nucleocapsid penetration into the cytoplasm after hemifusion during rubella virus entry. mBio 13(6), e0169822, 2022
  • Shirasago Y, Fukazawa H, Nagase S, Shimizu Y, Mizukami T, Wakita T, Suzuki T, Tani H, Kondoh M, Kuroda T, Yasuda S, Sato Y, Hanada K, Fukasawa M*. A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection. Sci. Rep. 12, 20243, 2022.
  • Kobayashi K, Arita M, Sakai S, Kojima H, Senda M, Senda T, Hanada K, Kato R. Ligand Recognition by the Lipid Transfer Domain of Human OSBP Is Important for Enterovirus Replication. ACS infectious diseases 8(6) 1161-1170, 2022.
  • Mutoh T*, Niimi Y, Sakai S, Watanabe H, Ueda A, Shima S, Igarashi Y. Species-specific accumulation of ceramides in cerebrospinal fluid from encephalomyeloradiculoneurpathy patients associated with peripheral complement activation: A pilot study. BBA - Molecular and Cell Biology of Lipids, 1867(3):159092, 2022.
  • Hanada K, Sakai S, Kumagai K. Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT. IJMS, 14;23(4):2098, 2022.
  • Fujita J, Taniguchi M, Hashizume C, Ueda Y, Sakai S, Kondo T, Hashimoto-Nishimura M, Hanada K, Kosaka T, Okazaki T*. Nuclear ceramide is associated with ATM activation in the neocarzinostatin-induced apoptosis of lymphoblastoid cells. Mol. Pharm, 101(5):322-333, 2022.

 

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